Katsumi imoto11/9/2022 Early gastric cancer endoscopic diagnosis of depth of invasion. Depth-predicting score for differentiated early gastric cancer. Diagnostic performance of conventional endoscopy in the identification of submucosal invasion by early gastric cancer: the “non-extension sign” as a simple diagnostic marker. Japanese gastric cancer treatment guidelines 2014 (ver. 76 points, respectively, P < 0.0001).Ĭonclusions Our e-learning program showed that self-study quizzes consolidated knowledge of the non-extension sign and improved diagnostic ability of endoscopists for invasion depth of EGC. Participants who completed the self-study quizzes showed significantly better post-test 2 scores compared with the non-self-study group (80 vs. Video lectures improved the mean score of post-test 1 from 72 to 77 points. Post-test 1 was completed by 415 endoscopists and 208 were allocated to the self-study group and 207 to the non-self-study group. Two hundred and four in the self-study group and 205 in the non-self-study group were included in the analysis. Results A total of 423 endoscopists completed the pretest and were enrolled. The perfect score for the tests was set as 100 points. The primary endpoint was the difference in post-test 2 scores between the groups. Finally, participants in both groups undertook post-test 2. The participants were then randomly allocated to either the self-study or non-self-study group, and participants in the first group completed the self-study program that comprised 100-case quizzes. After completing a pretest, the participants watched video lectures and undertook post-test 1. Methods We conducted a prospective randomized controlled study that recruited endoscopists throughout Japan. Marteijn JA, Bekker-Jensen S, Mailand N et al (2009) Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.Referred to by: Should we recommend use of non-extension sign in Europe?Endosc Int Open 2019 07(07): E883-E884īackground and study aims We developed an e-learning program for endoscopic diagnosis of invasion depth of early gastric cancer (EGC) using a simple diagnostic criterion called non-extension sign, and the contribution of self-study quizzes to improvement of diagnostic accuracy was evaluated.Marteijn JA, Bekker-Jensen S, Mailand N et al (2009) Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.Sertic S, Pizzi S, Cloney R et al (2011) Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation. Ogi T, Limsirichaikul S, Overmeer RM et al (2010) Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.Hong Z, Jiang J, Hashiguchi K et al (2008) Recruitment of mismatch repair proteins to the site of DNA damage in human cells.Moser J, Kool H, Giakzidis I et al (2007) Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner.Staresincic L, Fagbemi AF, Enzlin JH et al (2009) Coordination of dual incision and repair synthesis in human nucleotide excision repair.Volker M, Moné MJ, Karmakar P et al (2001) Sequential assembly of the nucleotide excision repair factors in vivo.Moné MJ, Volker M, Nikaido O et al (2001) Local UV-induced DNA damage in cell nuclei results in local transcription inhibition.Katsumi S, Kobayashi N, Imoto K et al (2001) In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts.Gillet LCJ, Schärer OD (2006) Molecular mechanisms of mammalian global genome nucleotide excision repair.
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